microsatelliteinstabilityhighmsih

Microsatellites are short, repeated sequences of DNA. Microsatellite instability-high cancer cells may have a defect in the ability to correct mistakes that ...

由 R Bonneville 著作 · 2017 · 被引用 1106 次 — Somatic mutational burden correlates with microsatellite instability high (MSI-H) status within adrenocortical carcinoma (ACC) and cervical ...

Microsatellite instability (MSI) is the condition of genetic hypermutability (predisposition to mutation) that results from impaired DNA mismatch repair ...

MSI testing looks at the length of certain DNA microsatellites from the tumor sample to see if they have gotten longer or shorter as a measure of instability.

Microsatellite instability testing uses surrogate loci to identify the mutator phenotype, or high-frequency MSI (MSI-H), in a highly sensitive manner. An ...

由 LA Gian 著作 · 2018 · 被引用 178 次 — MSI occurs in around 15% of all CRC tumors in white populations (18-19). It arises as a result of defective MMR caused by the failure of one of the four main ...

由 K Li 著作 · 2020 · 被引用 348 次 — The patients with high microsatellite instability (MSI-H)/mismatch repair deficient (dMMR) tumors recently have been reported that can ...

Defects in MMR can lead to microsatellite instability-high (MSI-H), which can be found in many types of cancer. MSI-H or mismatch repair deficient (dMMR) ...

2023年3月6日 — Instability occurs when these genes aren't functioning. As the DNA replicates, errors are introduced and don't get corrected, and as it ...